Thelansis

  Neuropathic Corneal pain arises from a primary lesion or dysfunction within the nervous system and can manifest in the cornea. However, neuropathic corneal pain (NCP) remains poorly defined as a distinct clinical entity. The pathophysiology of NCP involves peripheral nerve injury, often due to direct trauma, inflammation, or toxicity, leading to the release of pro-inflammatory neuropeptides from damaged nerves and cytokines from surrounding healthy nerves, thereby inducing peripheral sensitization. The sensory nervous system comprises sensory neurons, neural pathways, and the sensory cortex. Nociceptors, specialized receptors responsible for pain perception, can generate action potentials in response to various stimuli, including thermal, mechanical, chemical, or polymodal inputs. These nociceptors are centrally connected to higher-order somatosensory pain pathways and the thalamus, where pain perception occurs. Peripheral sensitization in NCP is initiated by corneal nerve inju...