Chordoma – Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2023 To 2033

Chordoma, an infrequent malignant tumor, can manifest in the spine and the base of the skull. This type of cancer originates from the notochord—a crucial embryonic mesodermal structure responsible for signaling tissue organization and differentiation—and accounts for 1 to 4% of all malignant bone tumors. In humans, the notochord eventually transforms into the nucleus pulposus. Chordomas predominantly occur in three locations: 50% in the sacrum, 35% in the skull base, and 15% in the vertebral bodies of the mobile spine (most commonly, the C2 vertebra, followed by the lumbar and thoracic spine). These tumors present as slow-growing, locally invasive growths, with rare occurrences of distant metastases, typically in the advanced stages of the disease. Despite their relatively benign nature, chordomas carry a significant risk of recurring locally. Chordomas are classified into four subtypes: conventional, poorly differentiated, dedifferentiated, and chondroid. Conventional (classic) c...