Thelansis

Leber's hereditary optic neuropathy (LHON) is characterized by rapid bilateral loss of central vision. Primarily male patients are affected in early adult life. Optic atrophy commonly appears within 3 months after the onset of the disease. Relatives in the maternal line often show peripapillary microangiopathy typical for LHON. In most cases, symptoms begin with one eye first, followed a few weeks later by visual failure in the other eye. Extremely rarely there may be neurologic abnormalities, such as peripheral neuropathy, postural tremor, nonspecific myopathy, and movement disorders. LHON is caused by mutations in mitochondrial DNA and is strictly transmitted by maternal inheritance. The acute phase of LHON is characterized by a loss of central vision, including blurring and reduced perception of color. Individuals usually lose vision in one eye first and then lose vision in the other eye after two to three months. The atrophic phase is characterized by bilateral optic atrophy, r...

 Leber's hereditary optic neuropathy (LHON) is characterized by rapid bilateral loss of central vision. Primarily male patients are affected in early adult life. Optic atrophy commonly appears within 3 months after the onset of the disease. Relatives in the maternal line often show peripapillary microangiopathy typical for LHON. In most cases, symptoms begin with one eye first, followed a few weeks later by visual failure in the other eye. Extremely rarely there may be neurologic abnormalities, such as peripheral neuropathy, postural tremor, nonspecific myopathy, and movement disorders. LHON is caused by mutations in mitochondrial DNA and is strictly transmitted by maternal inheritance. The acute phase of LHON is characterized by a loss of central vision, including blurring and reduced perception of color. Individuals usually lose vision in one eye first and then lose vision in the other eye after two to three months. The atrophic phase is characterized by bilateral optic atrophy, ...

Leber's hereditary optic neuropathy (LHON) is characterized by rapid bilateral loss of central vision. Primarily male patients are affected in early adult life. Optic atrophy commonly appears within 3 months after the onset of the disease. Relatives in the maternal line often show peripapillary microangiopathy typical for LHON. In most cases, symptoms begin with one eye first, followed a few weeks later by visual failure in the other eye. Extremely rarely there may be neurologic abnormalities, such as peripheral neuropathy, postural tremor, nonspecific myopathy, and movement disorders. LHON is caused by mutations in mitochondrial DNA and is strictly transmitted by maternal inheritance. The acute phase of LHON is characterized by a loss of central vision, including blurring and reduced perception of color. Individuals usually lose vision in one eye first and then lose vision in the other eye after two to three months. The atrophic phase is characterized by bilateral optic atrophy, r...