Thelansis

  Gastrointestinal stromal tumors (GISTs) are the predominant mesenchymal tumors in the gastrointestinal tract. They primarily occur in the stomach (50%-60%) and small intestine (30%-35%), while their occurrence in the colon and rectum is less common (5%), and in the esophagus, it is rare (<1%). Additionally, GISTs can develop within the abdominal cavity, specifically in the omentum, mesentery, or retroperitoneum (occurring in less than 5% of all GISTs). Specific mutations in the KIT gene drive the majority of GISTs (75%-80%) or PDGFRA gene (10%). However, around 10%-15% of GISTs do not exhibit detectable mutations in KIT or PDGFRA and are called KIT/PDGFRA wild-type GISTs. Succinate dehydrogenase comprises four subunit proteins (SDHA, SDHB, SDHC, and SDHD) and two assembly factors (SDHAF1 and SDHAF2). SDHA and SDHB form the catalytic component of succinate-coenzyme Q reductase, whereas SDHC and SDHD comprise the anchoring component that attaches the complex to the inner mitoc...

 Gastrointestinal stromal tumors (GISTs) are the predominant mesenchymal tumors in the gastrointestinal tract. They primarily occur in the stomach (50%-60%) and small intestine (30%-35%), while their occurrence in the colon and rectum is less common (5%), and in the esophagus, it is rare (<1%). Additionally, GISTs can develop within the abdominal cavity, specifically in the omentum, mesentery, or retroperitoneum (occurring in less than 5% of all GISTs). Specific mutations in the KIT gene drive the majority of GISTs (75%-80%) or PDGFRA gene (10%). However, around 10%-15% of GISTs do not exhibit detectable mutations in KIT or PDGFRA and are called KIT/PDGFRA wild-type GISTs. Succinate dehydrogenase comprises four subunit proteins (SDHA, SDHB, SDHC, and SDHD) and two assembly factors (SDHAF1 and SDHAF2). SDHA and SDHB form the catalytic component of succinate-coenzyme Q reductase, whereas SDHC and SDHD comprise the anchoring component that attaches the complex to the inner mitochon...