Thelansis

 Scleroderma, a connective tissue disorder, primarily manifests as thickened and hardened skin. There are two main types: localized and systemic, also known as systemic sclerosis. In localized scleroderma, the condition primarily affects the skin and may also impact muscles and bones. The exact causes of scleroderma remain unclear, but some evidence suggests genetic and environmental factors play a role in its development. Silica and specific organic solvents are recognized risk factors for systemic scleroderma. These factors trigger an immune system response, damaging blood vessels and tissues and forming scar tissue and excess collagen accumulation. Raynaud's phenomenon (RP) is often the initial symptom of scleroderma, sometimes appearing years before other signs of the disease. It is a visible expression of a systemic vascular issue fundamental to scleroderma's development. Three primary mechanisms contribute to scleroderma development: vascular anomalies, excess fibrosis, a...

  Scleroderma is the common name for a broad class of rare, fatal, inherited disorders of the nervous system also known as neuronal ceroid lipofuscinoses, or NCLs. Etiology- Scleroderma is an inherited genetic disorder that appears to affect the function of tiny bodies within cells called lysosomes. In Scleroderma/NCLs, the mutated genes do not produce the proper amounts of proteins important for lysosomal function. Epidemiology- Scleroderma and other forms of NCL are relatively rare, occurring in an estimated 2 to 4 of every 100,000 births in the United States. The competitive landscape of Scleroderma includes country-specific approved as well as pipeline therapies. Any asset/product-specific designation or review and Accelerated Approval are being tracked and supplemented with analyst commentary. KOLs insights of Scleroderma across 8 MM market from the center of Excellence/ Public/ Private hospitals participated in the study. Insights around current treatment landscap...