Thelansis

  Mesothelioma is a type of cancer that develops in the lining that covers the outer surface of some of the body's organs. It's usually linked to asbestos exposure. Mesothelioma mainly affects the lining of the lungs (pleural mesothelioma), although it can also affect the lining of the tummy (peritoneal mesothelioma), heart, or testicles. The four types of mesothelioma are identified by the location in the body where tumors develop. Pleural and peritoneal types of mesothelioma are the most common. Pericardial and testicular mesothelioma accounts for less than 2% of cases combined. According to Thelansis disease modeling data and literature review estimated, approximately 3350 cases of malignant mesothelioma are diagnosed annually. In the absence of occupational exposure to asbestos, the incidence is 0.1-0.25 per 100,000 population in both sexes. The risk of mesothelioma is increased in polluted areas by 2-10 fold compared with non-polluted areas. In...

  Evolution of I/O targeted therapies and expectations of cancer patients and physicians Over the past five years, antibodies have become the best-selling drugs in the pharmaceutical market; eight of the top ten bestselling drugs worldwide were biologics. The global therapeutic monoclonal antibody market is expected to generate revenue of $300 billion by 2025.   Immunotherapy is a promising cancer therapy where the immune system is manipulated to attack cancer cells. It has hinted at better patient survival and quality of life compared to the other methods. The effectiveness of immunotherapy has been known from as early as the 19th century when, William Coley, MD used a concoction of inactivated bacteria (popularly known as Coley’s toxin) to infect the tumor area resulting in remission of the tumor. Yet, there was insufficient understanding of the mechanism. It was nearly half a century later that concepts of immune system response shed light on the potential of cancer i...