Thelansis

  In critically ill patients within the intensive care unit, including those with severe influenza and severe COVID-19 infection, Invasive Aspergillosis (IA) is increasingly recognized. While primarily affecting the lungs, aspergillosis can manifest in virtually any organ system, and disseminated disease is prevalent in patients with prolonged granulocytopenia following chemotherapy. Despite progress in diagnosing and treating IA, mortality rates remain elevated, especially in immunosuppressed individuals. Triazole resistance has emerged in some global regions, posing a significant concern for management due to limited options for treating azole-resistant infections and the potential for prophylaxis failure in immunocompromised hosts. Cryptic species of Aspergillus, which are morphologically challenging to identify, have gained importance due to higher azole antifungal minimum inhibitory concentrations (MICs), difficulty in differentiation based on appearance alone, and the uncertain