Thelansis

 Limb-Girdle Muscular Dystrophy Type 2 (LGMD2A, LGMD2B, LGMD2C, LGMD2D, LGMD2E, LGMD2F, LGMD2G, LGMD2I, LGMD2J, LGMD2L, Others (LGMD2H, LGMD2K, LGMD2M-Z)) includes forms of autosomal recessive characterized by progressive weakness of the muscles of the pelvic girdle, legs, arms, and shoulders. Progression of muscle weakness may be slow or rapid and may vary even among individuals in the same family. Intelligence is normal. The age of onset ranges from subgroup to subgroup. Overall, the beginning is more common in childhood, but it may occur in adulthood. Diagnosis of LGMD2A is complicated by phenotypic variability, lack of precise protein analysis, and absence of mutational hot spots in the CAPN3 gene. Children between the ages of 8-15 may range from 2-to 40 years of age. Most cases are characterized by muscle .weakness affecting the hip-girdle area, although the hip adductor muscles may be spared. ·        The prevalence of Limb-girdle muscular dyst...

  Limb-Girdle Muscular Dystrophy Type 2 (LGMD2A, LGMD2B, LGMD2C, LGMD2D, LGMD2E, LGMD2F, LGMD2G, LGMD2I, LGMD2J, LGMD2L, Others (LGMD2H, LGMD2K, LGMD2M-Z)) includes forms of autosomal recessive characterized by progressive weakness of the muscles of the pelvic girdle, legs, arms, and shoulders. Progression of muscle weakness may be slow or rapid and may vary even among individuals in the same family. Intelligence is normal. The age of onset ranges from subgroup to subgroup. Overall, the beginning is more common in childhood, but it may occur in adulthood. Diagnosis of LGMD2A is complicated by phenotypic variability, lack of precise protein analysis, and absence of mutational hot spots in the CAPN3 gene. Children between the ages of 8-and 15 may range from 2-to 40 years of age. Most cases are characterized by muscle .weakness affecting the hip-girdle area, although the hip adductor muscles may be spared. The prevalence of Limb-girdle muscular dystrophy type 2 varies from 47 to 53 ...