Thelansis

  Diabetic peripheral neuropathy (DPN) is a common and chronic complication of diabetes, leading to distressing and expensive clinical issues such as foot ulcers, leg amputations, and neuropathic pain (painful DPN). This condition is linked to increased mortality and mainly results in diabetic foot ulcers and neuropathic pain. Typically, DPN is the most prevalent form of neuropathy in diabetes, affecting both sensory and motor nerves in a peripheral distribution. However, individuals' impact on small and large sensory and motor fibers varies. DPN's most significant risk factors are the duration of diabetes and glycemic control. Additional risk factors for cardiovascular disease, such as obesity, hypertension, smoking, and dyslipidemia, are also associated with DPN. The pathogenesis of DPN is complex and not fully understood. DPN risk is low at the diagnosis of type 1 diabetes, so foot screening should begin five years after diagnosis. Limited treatments are available to rever...