Thelansis

  Charcot-Marie-Tooth disease type 1 (CMT1) is a collection of demyelinating peripheral neuropathies inherited autosomal dominant. It is characterized by weakness and wasting of muscles in the distal regions of the body, loss of sensation, foot deformities, and reduced nerve conduction velocity. The age at which CMT1 manifests can vary significantly, ranging from infancy to the fourth decade or later. Generally, symptoms appear between the first and second decade of life, although the full clinical presentation may emerge later. The severity of the disease can range from very mild cases that go unnoticed to substantial weakness and disability. Affected individuals typically experience weakness in the distal muscles, symmetric wasting (mainly in the peroneal muscles), and diminished or absent tendon reflexes. Sensory deficits, including impaired position sense, vibration sense, and pain/temperature sensation, are common in the feet and may later affect the hands. Pes cavus (high a...

 Charcot-Marie-Tooth disease type 1 (CMT1) is a collection of demyelinating peripheral neuropathies inherited autosomal dominant. It is characterized by weakness and wasting of muscles in the distal regions of the body, loss of sensation, foot deformities, and reduced nerve conduction velocity. The age at which CMT1 manifests can vary significantly, ranging from infancy to the fourth decade or later. Generally, symptoms appear between the first and second decade of life, although the full clinical presentation may emerge later. The severity of the disease can range from very mild cases that go unnoticed to substantial weakness and disability. Affected individuals typically experience weakness in the distal muscles, symmetric wasting (mainly in the peroneal muscles), and diminished or absent tendon reflexes. Sensory deficits, including impaired position sense, vibration sense, and pain/temperature sensation, are common in the feet and may later affect the hands. Pes cavus (high arch...