Thelansis

 Hypophosphatemia, characterized by abnormally low phosphate levels in the blood serum, can have multiple causes. However, clinically significant acute hypophosphatemia is relatively rare. It is observed in specific situations, including the recovery phase of diabetic ketoacidosis, acute alcohol use disorder, severe burns, receiving total parenteral nutrition (TPN), refeeding after prolonged undernutrition, and severe respiratory alkalosis. Acute severe hypophosphatemia, with serum phosphate levels below 1 mg/dL (0.32 mmol/L), is often the result of shifts of phosphate within cells, sometimes superimposed on chronic phosphate depletion. It is often asymptomatic, severe chronic depletion can lead to anorexia, muscle weakness, and osteomalacia. Profound hypophosphatemia may also cause severe neuromuscular disturbances, including progressive encephalopathy, seizures, coma, and even death. Muscle weakness associated with profound hypophosphatemia may be accompanied by rhabdomyolysis, p...