Thelansis

  Gastroparesis is characterized by a measurable delay in gastric emptying, devoid of any indications of mechanical blockage. In cases of poorly managed diabetes, diabetic gastroparesis can arise, stemming from disruptions in the autonomic nervous system, neurons, specialized pacemaker cells (interstitial cells of Cajal, ICC) in the stomach and intestine, and the smooth muscle cells in the gastrointestinal tract. Poorly controlled diabetes often leads to hyperglycemia (blood glucose exceeding 200 mg/dL), a contributing factor to diabetic gastroparesis due to neuropathy resulting from prolonged hyperglycemia. Unlike acute hyperglycemia, which can cause delayed gastric emptying but is usually reversible with improved glycemic control, chronic hyperglycemia-associated gastroparesis does not resolve as readily. Gastric emptying hinges on the synchronization of fundal tone and antral phasic contraction, coupled with the simultaneous inhibition of pyloric and duodenal contractions. Thi...