Thelansis

 Myasthenia gravis (MG) is a clinically heterogeneous autoimmune disorder affecting the neuromuscular junction. It is characterized by fatigable weakness of voluntary muscles. The onset of MG can occur at any age, but in the adult-onset form, there is a bimodal peak. Generalized MG, which commonly affects women under the age of 40, has a higher prevalence than in men. Men, on the other hand, are more likely to develop MG after the age of 60. The underlying cause of MG is autoimmune in nature. Self-reactive antibodies target acetylcholine receptors, which are crucial for facilitating muscle contraction and movement. However, approximately 15% of individuals with generalized MG do not have antibodies against acetylcholine receptors. Instead, these patients possess self-reactive antibodies against other important molecules involved in nerve-muscle communication, such as muscle-specific kinase (MuSK). Nearly all patients who develop generalized MG do so within two or three years after ...