Thelansis

 Myotonic dystrophy type 1 (DM1) is the most common form of muscular dystrophy in adults. DM1 is a dominant disorder characterized by multisystemic clinical features affecting skeletal muscle, heart, and the nervous and endocrine systems. ·        The prevalence varies by region and is most common in individuals of European descent. According to Thelansis disease modeling data, results of literature reviews, surveys, and registry analyses combined prevalence reported as 1 in 8,000 (12.5 per 100,000). ·        Myotonic Dystrophy Type 1 (DM1) is caused by the expansion of a CTG repeat in the 3' noncoding region of the DMPK gene on chromosome 19q13.3, which codes for the myotonic dystrophy protein kinase. ·        Normal individuals have between 5 and 37 repeats, but symptomatic patients typically have > 50 repeats. DM1 is categorized into four subtypes: congenital, childhood, classic,...