Thelansis

  Acute Ischemic Stroke is characterized by the impact of an obstruction within a blood vessel supplying blood to the brain. Stroke is one of the leading causes of death and disability worldwide. The blockage of blood flow to the brain inevitably causes acute ischemic stroke. Once the tissue oxygenation starts, depending on the time elapsed, the patient's situation changes—the lesser the time, the better the prognosis. At the cellular level, the sudden interruption or blockage of blood flow to the brain due to a blood clot (thrombus) or a plaque (fatty deposits) deprives the brain tissue of the necessary nutrients and oxygen, which leads to irreversible brain tissue damage. Ischemic stroke causes mitochondrial cell death. TPA is the gold standard for AIS treatment and is associated with improved clinical patient outcomes. The sooner the IV tPA is administered after stroke symptoms, the better the result.   Blood-brain barrier (BBB) disruption in acute ischemic stroke varie...