Thelansis

  Von Willebrand Disease (VWD) is the most common inherited bleeding disorder, characterized by phenotypic forms as follows: ·        Type 1: An autosomal dominant disease caused by a partial quantitative deficiency of von Willebrand factor (VWF), with incomplete penetrance at around 60%. ·        Type 2: An autosomal dominant disease with several qualitative defects in VWF. It has four subtypes (2A, 2B, 2N, 2M), with 2A being the most common variant. ·        Type 3: An autosomal recessive disease caused by a complete quantitative defect in VWF, resulting in undetectable levels and severe bleeding. The VWF gene's polymorphic nature leads to various VWF levels and functions, resulting in varying disease presentations and severity. Common symptoms of VWD include frequent nosebleeds lasting over 10 minutes, prolonged bleeding from cuts or injuries, easy bruising, iron deficiency anemia, ...