Thelansis

 Hunter syndrome, also recognized as Mucopolysaccharidosis Type II (MPS-II), is a multisystem disorder linked to the X chromosome, marked by the accumulation of glycosaminoglycans. It predominantly affects males, with rare instances of heterozygous females exhibiting symptoms. The age at which symptoms appear, the disease's severity, and its progression rate vary widely among affected males. In individuals with an early and rapidly progressing form of the disease, central nervous system (CNS) involvement is a prominent feature, primarily characterized by progressive cognitive decline. Additionally, they experience advancing airway problems and cardiac issues, typically leading to mortality within the first or second decade of life. Conversely, those with a slowly progressing form of the disease do not experience CNS impairment. However, the impact of glycosaminoglycan accumulation on other organ systems may progress to a similar degree as in individuals with progressive cognitive d...