Thelansis

  Primary immunodeficiency disorder (PID) encompasses various conditions arising from immune system development or function abnormalities. PIDs are categorized into two main groups: those affecting adaptive immunity (such as T cell, B cell, or combined immunodeficiencies) and those impacting innate immunity (like phagocyte and complement disorders). The clinical presentation of T-cell (cellular) disorders and combined immunodeficiencies (CIDs) can vary based on the underlying defect in the adaptive immune system. Hence, maintaining a high clinical suspicion is crucial for promptly diagnosing these conditions. Individuals with specific T-cell defects might exhibit lymphopenia (reduced lymphocyte levels) and neutropenia (decreased neutrophil levels). Treatment strategies typically involve immunoglobulin (Ig) replacement therapy, prophylactic antibiotics, and antifungal medications to mitigate infection risks. Additionally, gene therapy, which entails introducing...