Thelansis

 Neuroendocrine tumors, arising from neuroendocrine cells, are malignant growths. They are most frequently found in the gastrointestinal tract (48%), lungs (25%), and pancreas (9%). However, they can also develop in other organs like the breast, prostate, thymus, and skin. Neuroendocrine cells can produce hormones, such as serotonin, leading to symptoms like flushing and diarrhea. Additionally, they produce proteins like chromogranin A, which serve as biomarkers for NETs. Neuroendocrine tissues commonly express somatostatin receptors on their cell surfaces. Three clinicopathologic features—grade, differentiation, and stage—determine the biological behavior of NETs. NETs can either be discovered incidentally or suspected due to clinical symptoms. When NETs cause symptoms through hormone secretion, they are termed "functioning," and those that do not produce active hormones are termed "nonfunctioning." Both types present late with nonspecific symptoms, often leading t...