Thelansis

  Dupuytren's disease, also known as Palmar fibromatosis, is characterized by the gradual thickening and contraction of the palmar fascia, a layer of tissue beneath the skin and above the tendons, nerves, blood vessels, and bones in the palm and fingers. This fibrous layer stabilizes the skin on the palm side of the hand, preventing excessive mobility. However, in individuals with Dupuytren's, the fascia thickens over time, resulting in a tightening or shortening effect. Typically, the initial indication of Dupuytren's is the formation of nodules, or lumps of tissue, beneath the skin in the palm. As the condition progresses slowly over the years, these nodules may evolve into cords, leading to contractures. Signs and symptoms of Dupuytren's include nodules, cords, and contractures. Dupuytren's disease is not life-threatening and does not metastasize to vital organs. A benign proliferation of myofibroblasts and fibroblasts characterizes it. While the exact cause re...