Thelansis

  Neutropenia is defined as an absolute neutrophil count (ANC) of less than 1500 per microliter (1500/microL). Severe neutropenia is defined as less than 500 per microliter (500/microL).   Epidemiology- The causes of primary defects of neutrophil function include failure of the following: Adhere to endothelial cells, Migrate into inflammation sites (abnormal chemotaxis), Ingest and kill bacteria, Produce microbicidal compounds to kill fungi and other pathogens, Form phagolysosomes, Make high concentrations of toxic reactive oxygen species. Low levels of neutrophils may be due to hypoplastic bone marrow, an infection, radiation exposure, tumour infiltration of the bone marrow, myelofibrosis, prolonged exposure to a drug, or a hereditary disorder. Congenital neutropenia or Kostmann syndrome is acquired in an autosomal recessive fashion. Drugs are known to cause neutropenia to include: Quinidine Aminopyrine, Cephalosporin, Sulfonamides, Hydralazine, Penicillins, Heavy m...