Usher Syndrome – Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report – 2023 To 2033
Usher syndrome is a group of inherited disorders characterized by dual sensory impairment of the auditory and visual systems. It is the most common cause of combined sight and hearing loss, accounting for more than half of deaf-blindness cases. Nine causative genes have been identified and confirmed responsible for the syndrome when mutated, including MYO7A, USH1C, CDH23, PCDH15, and USH1G for Usher type 1; USH2A, ADGRV1, and WHRN for Usher type 2; and CLRN1 for Usher type 3. Usher syndrome is clinically and genetically heterogeneous and is divided into three distinct clinical subtypes: Usher 1, Usher 2, and Usher 3. Usher 1 is the most severe subtype, in which patients exhibit severe to profound bilateral congenital sensorineural hearing loss, most frequently non-progressive, with vestibular areflexia. It accounts for approximately 25-44% of all Usher syndrome cases. Usher 2 represents over half of all cases. Sensorineural hearing loss is typically described as sloping, mild t...
