Thelansis

 

 An opioid overdose occurs when a person has excessive unopposed stimulation of the opiate pathway. This can lead to decreased respiratory effort and possibly death. The frequency of opioid overdose is rapidly increasing. Opiates are frequently prescribed for moderate to severe pain in the US. They are often prescribed alone or in combination with non-steroidal anti-inflammatory drugs or muscle relaxants. Opioids work via the endogenous opioid system by acting as a potent agonist to the mu receptor. This results in a complex cascade of intracellular signals resulting in dopamine release, blockade of pain signals, and a resulting sensation of euphoria. Opioid receptors are located in the brain, spinal cord, and gut. In overdose, there is an excessive effect on the portion of the brain regulating respiratory rate, resulting in respiratory depression and eventually death. ·        In the USA, ~465,000 visits to the emergency rooms related to opiates in ...

  An opioid overdose occurs when a person has excessive unopposed stimulation of the opiate pathway. This can lead to decreased respiratory effort and possibly death. The frequency of opioid overdose is rapidly increasing. Opiates are frequently prescribed for moderate to severe pain in the US. They are often prescribed alone or in combination with non-steroidal anti-inflammatory drugs or muscle relaxants. Opioids work via the endogenous opioid system by acting as a potent agonist to the mu receptor. This results in a complex cascade of intracellular signals resulting in dopamine release, blockade of pain signals, and a resulting sensation of euphoria. Opioid receptors are located in the brain, spinal cord, and gut. In overdose, there is an excessive effect on the portion of the brain regulating respiratory rate, resulting in respiratory depression and eventually death. In the USA ~465,000 visits to the emergency rooms related to opiates in 2019. However more than 20 MN populatio...