Thelansis

 Scleroderma, a connective tissue disorder, primarily manifests as thickened and hardened skin. There are two main types: localized and systemic, also known as systemic sclerosis. In localized scleroderma, the condition primarily affects the skin and may also impact muscles and bones. The exact causes of scleroderma remain unclear, but some evidence suggests genetic and environmental factors play a role in its development. Silica and specific organic solvents are recognized risk factors for systemic scleroderma. These factors trigger an immune system response, damaging blood vessels and tissues and forming scar tissue and excess collagen accumulation. Raynaud's phenomenon (RP) is often the initial symptom of scleroderma, sometimes appearing years before other signs of the disease. It is a visible expression of a systemic vascular issue fundamental to scleroderma's development. Three primary mechanisms contribute to scleroderma development: vascular anomalies, excess fibrosis, a...