Thelansis

  Axial spondyloarthritis (axSpA), which includes both ankylosing spondylitis (AS) and non-radiographic axial SpA, is the most common type of chronic inflammatory arthritis affecting the axial skeleton (AS). AS affects 0.1–0.5 percent of the population and is characterized by inflammatory back pain, radiographic sacroiliitis, excess spinal bone formation, and a high prevalence of HLA–B27. Although non-radiographic axial SpA shares several features with AS, advanced sacroiliac joint damage and spine ankylosis are absent. The severity of arthralgia, stiffness, and limited flexibility vary widely among patients and throughout axial SpA. The skeletal disease may be accompanied by uveitis, psoriasis, and inflammatory bowel disease (IBD). Axial SpA can impose substantial physical and social burdens on patients and interfere with day-to-day life. Axial SpA is associated with a significant disease burden, including significant pain, stiffness, and impaired physical function. Despite this b...