Thelansis

  Leukodystrophies are a group of genetic disorders characterized by the degeneration or abnormal formation of the white matter of the central nervous system (CNS). Various mechanisms, including lipid metabolism disorders, myelin protein disorders, organic acid metabolism disorders, and other unknown causes, cause these disorders. The pathological classification of leukodystrophies can be divided into demyelinating and hypomyelination subtypes based on the degree of destruction or abnormal myelin formation. Some examples of leukodystrophies include X-linked adrenoleukodystrophy (ALD), metachromatic leukodystrophy (MLD), globoid cell leukodystrophy (Krabbe's disease), Alexander's disease, Canavan's disease, Pelizaeus-Merzbacher disease (PMD), and others. ALD is a subtype of leukodystrophy with diverse presentations, defined by the age of onset, the extent of involvement, and the progression of the disease. Childhood cerebral ALD occurs in approximately 35% of at-risk males...

Leukodystrophies are a group of genetic disorders characterized by the degeneration or abnormal formation of the white matter of the central nervous system (CNS). Various mechanisms, including lipid metabolism disorders, myelin protein disorders, organic acid metabolism disorders, and other unknown causes, cause these disorders. The pathological classification of leukodystrophies can be divided into demyelinating and hypomyelination subtypes based on the degree of destruction or abnormal myelin formation. Some examples of leukodystrophies include X-linked adrenoleukodystrophy (ALD), metachromatic leukodystrophy (MLD), globoid cell leukodystrophy (Krabbe's disease), Alexander's disease, Canavan's disease, Pelizaeus-Merzbacher disease (PMD), and others. ALD is a subtype of leukodystrophy with diverse presentations, defined by the age of onset, the extent of involvement, and the progression of the disease. Childhood cerebral ALD occurs in approximately 35% of at-risk males, an...