Thelansis

 Spinocerebellar ataxia (SCA) represents a diverse and heterogeneous collection of autosomal dominant degenerative disorders. These conditions are characterized by the progressive degeneration of the cerebellum and its associated nerve connections, along with typical involvement of structures like the basal ganglia, brainstem nuclei, pyramidal tracts, posterior column, anterior horn, peripheral nerves, and other parts of the nervous system. Clinically, SCAs manifest as cerebellar gait and limb ataxia, accompanied by various associated symptoms such as dysmetria, dysdiadochokinesia, intention tremor, dysarthria, and nystagmus. Additionally, extracerebellar signs may emerge, including ophthalmoplegia, pyramidal signs, movement disorders (like parkinsonism, dystonia, myoclonia, and chorea), dementia, epilepsy, visual impairments (such as pigmentary retinopathy), lower motor neuron disease, and peripheral neuropathy. Several types of spinocerebellar ataxia exhibit a phenomenon known as...

  Spinocerebellar ataxia (SCA) is an extensive and heterogeneous group of autosomal dominant degenerative diseases characterized by progressive cerebellum degeneration and its afferent and efferent connections. The basal ganglia, brainstem nuclei, pyramidal tracts, posterior column, anterior horn, peripheral nerve, and other nervous system structures are typically also affected. SCAs are clinically characterized by the presence of cerebellar gait and limb ataxia (with dysmetria, dysdiado chokinesia, intention tremor, dysarthria, and nystagmus), which may be accompanied by extracerebellar signs such as ophthalmoplegia, pyramidal signs, movement disorders (including parkinsonism, dystonia, myoclonia, and chorea), dementia, epilepsy, visual disorders (including pigmentary retinopathy), lower motor neuron disease and peripheral neuropathy. SCA accounts for 3% to 5% of the ataxic diagnosed population, with an estimated prevalence of 1 to 5 cases in 100,000 people. Thelan...