Thelansis

  Anaphylaxis is a severe, systemic hypersensitivity reaction that is rapid in onset and characterized by life-threatening airway, breathing, and circulatory problems, usually associated with skin and mucosal changes. Anaphylaxis is a severe, systemic hypersensitivity reaction that is rapid in onset and characterized by life-threatening airway, breathing, and circulatory problems, usually associated with skin and mucosal changes—caused by the interaction of a foreign antigen with specific IgE antibodies found on tissue mast cells and peripheral blood basophils. The subsequent release of histamine and other bioactive mediators caused by this interaction results in smooth muscle spasm, bronchospasm, mucosal edema, inflammation, and increased capillary permeability. These systemic changes characteristically show clinical manifestations in seconds or minutes of antigen exposure. The lifetime prevalence of anaphylaxis is currently estimated at 0.05-2 % in the USA and ~3 % in Europe. S...