Thelansis

  Anti-Glomerular Basement Membrane (anti-GBM) Disease is a rare form of small vessel vasculitis that affects the kidney and lung capillary beds. It is an archetypic autoimmune disease caused by the development of directly pathogenic autoantibodies targeting a well-characterized autoantigen expressed in the basement membranes of these organs. The body creates autoantibodies that recognize and attach to the basement membrane, part of the wall of capillary blood vessels in the kidneys and lungs. Once the autoantibodies bind to the basement membrane, this creates a signal to the body’s immune system to attack. However, the inciting events that induce the autoimmune response. Environmental factors may trigger the disease in genetically susceptible individuals, such as the current infection. Most patients develop widespread glomerular crescent formation, presenting with signs and symptoms of rapidly progressing GN, and 40%–60% will have an alveolar hemorrhage at the same time. The treat...

  Anti-Glomerular Basement Membrane (anti-GBM) Disease is a rare form of small vessel vasculitis that affects the kidney and lung capillary beds. It is an archetypic autoimmune disease caused by the development of directly pathogenic autoantibodies targeting a well-characterized autoantigen expressed in the basement membranes of these organs. The body creates autoantibodies that recognize and attach to the basement membrane, part of the wall of capillary blood vessels in the kidneys and lungs. Once the autoantibodies bind to the basement membrane, this creates a signal to the body’s immune system to attack. However, the inciting events that induce the autoimmune response. In genetically susceptible individuals, environmental factors, such as the current infection, may trigger the disease. Most patients develop widespread glomerular crescent formation, presenting with signs and symptoms of rapidly progressing GN, and 40%–60% will have an alveolar hemorrhage at the same time. The tre...