Thelansis

  Isolated Growth Hormone Deficiency (IGHD) leads to childhood growth failure due to inadequate growth hormone (GH) action. IGHD can be caused by different mutations in genes and inherited differently. Most IGHD cases are sporadic and caused by hypothalamic or pituitary insults. Symptoms of IGHD vary in type and severity among affected individuals and include anterior hypopituitarism, delayed skeletal maturation, short stature, frequent infections in type III, delayed eruption of teeth, poor growth of nails, and increased cholesterol and LDL levels in the blood. IGHD type 1 is further classified into sub-types 1a and b, with IGHD type 1a being the most severe. IGHD type 2 is inherited in an autosomal dominant pattern and is often considered the most common form of IGHD, excluding idiopathic GHD. IGHD type 3 is an X-linked recessive disorder with a highly variable phenotype. IGHD type IA is caused by GH1 gene mutations and is inherited in an autosomal recessive manner. IGHD type IB ...