Thelansis

 The adult-onset of X-linked Adrenoleukodystrophy, called as Adrenomyeloneuropathy (AMN), is characterized by ABCD1 gene mutation, which results in impaired peroxisome function with an accumulation of very long chain fatty acids (VLCFA) and demyelination. Adrenomyeloneuropathy (AMN) is mild, progresses slowly and is associated with an average life span in the ages of 21-35 years. The main symptoms include stiffness, weakness, paralysis of the lower limbs and loss of coordination. Women who are carriers of the disease occasionally experience the same symptoms along with ataxia, hypertonia, mild peripheral neuropathy and urinary problems. Individuals with X-ALD who reach their adulthood develop myelopathy and neuropathy, leading to AMN, in the age group of 30-40 years. The spinal cord and limber nerves are the only areas that initially exhibit symptoms. Before MR imaging was available, AMN was often misdiagnosed as multiple sclerosis or hereditary spastic paraparesis (HSP). In the ma...