Thelansis

 Necrotizing enterocolitis (NEC) primarily afflicts preterm infants, reflecting the remarkable advances in neonatology that have enabled the survival of babies born at lower gestational ages, a feat unimaginable a few decades ago. It stands as one of the most devastating maladies encountered in neonatal intensive care, characterized by staggering rates of morbidity, mortality, and financial burden. Long-term consequences include intestinal strictures, adhesions, cholestasis, short bowel syndrome, failure to thrive, and neurodevelopmental delays. Regrettably, efforts to treat or prevent NEC have seen limited success. The underdeveloped physiological functions of preterm infants, including immature barrier function, circulatory regulation, motility, digestion, absorption, and immune defenses, contribute to the vulnerability to NEC. Furthermore, the delicate balance between inflammatory and tolerogenic immune responses must still be developed. Classic NEC often manifests with excessiv...