Thelansis

  Cutaneous T-cell lymphoma (CTCL), or "skin T-cell lymphomas," makes up roughly 4 percent of all NHL cases. It primarily impacts the skin. In its initial phases, CTCL cells are predominantly located in the skin. As the disease advances in patients, these cells can accumulate in the bone marrow, bloodstream, lymph nodes, and solid organs. The two most common subtypes of CTCL are mycosis fungoides (MF), which tends to be slow-growing in early stages, and the more aggressive "Sézary syndrome" (SS). FDA-approved treatments for progressive, persistent, or recurring CTCLs include Vorinostat and romidepsin. When used as single agents, these drugs can achieve an overall response rate of 30% to 35%, with only 2% to 6% of cases experiencing a complete response. While chemotherapeutic agents treat CTCLs, they are associated with severe side effects. In the case of early-stage disorders, topical chemotherapeutic agents such as mechlorethamine (nitrogen mustard) and carmustin...