Thelansis

 Cushing's Disease (CD), the leading cause of endogenous Cushing's Syndrome (CS), results from the persistent overproduction of ACTH by a pituitary corticotroph adenoma. CD predominantly affects females, with a female-to-male ratio of 4-5:1, except in prepubertal patients, where males are more commonly affected. The peak age of onset occurs between 25 and 40 years. CD symptoms include typical CS features like central obesity, facial rounding, hypercatabolism signs, skin hyperpigmentation, and, in some cases, corticotroph macro-adenoma, neurological complications. Cushing's syndrome can present with varying signs and symptoms. Prolonged exposure to elevated cortisol levels leads to evident manifestations such as weight gain, thin extremities, a rounded face, fat accumulation around the neck, a fatty hump between the shoulders, easy bruising, wide purple stretch marks, mainly on the abdomen, breasts, hips, and under the arms, and muscle weakness. The exact pathogenesis of pit...