Thelansis

  Castleman Disease (CD) encompasses a cluster of infrequent lymphoproliferative conditions involving enlarged lymph nodes displaying distinctive microscopic alterations, an extensive array of inflammatory indications, and laboratory irregularities. It can affect lymph nodes across various bodily regions, simulating non-cancerous and cancerous anomalies, such as those found in the neck, chest, abdomen, and pelvis. From a pathological standpoint, it can be categorized into hyaline vascular type (HV-CD), plasma cell type, mixed type, and Castleman disease associated with human herpesvirus (HHV)-8. On a pathogenic level, the plasma cell variant of Castleman Disease is associated with excess production of IL-6 and heightened expression of IL-6 receptors, triggering the proliferation of B lymphocytes and vasculogenesis, which in turn results in an array of systemic manifestations like fever, anemia, hypoproteinemia, and proteinuria. In some instances of mixed CD, an elevated IL-6 level is