Thelansis

 Primary immune thrombocytopenia (ITP) is an autoimmune condition affecting children and adults, characterized by a platelet count falling below 100 × 109/l. Clinical manifestations include petechiae, purpura, bruising, and noticeable bleeding, with a highly variable pattern. Primary ITP exhibits significant heterogeneity. The most common form of bleeding occurs in the mucocutaneous form, which involves gum bleeding, blood blisters in the mouth, and menorrhagia. Key features involve dysfunction in primary hemostasis and the loss of immune tolerance toward platelet and megakaryocyte antigens. ITP is more prevalent in women than in men and can be categorized based on disease duration as acute (<3 months), persistent (3 to 12 months), or chronic (>12 months). Adults are more likely to develop chronic ITP than children, with up to 60% of adults experiencing chronic disease, while only 20–30% of children have persistent thrombocytopenia at 12 months. The primary objectives of ITP ...