Thelansis

 Cholesteryl ester storage disease (CESD) is a chronic liver disease that results from an autosomal recessive condition due to a deficiency of lysosomal acid lipase (LAL). The LAL gene is situated on chromosome 10q23.2-q23.3, and this enzyme plays a crucial role in breaking down triglycerides and cholesteryl esters within lysosomes. Elevated cholesterol levels, high triglycerides, a deficiency of HDL, and the abnormal accumulation of lipids in various organs characterize CESD. This leads to hepatomegaly in the liver due to hepatic steatosis and fibrosis, potentially resulting in micronodular cirrhosis. Onset typically occurs during childhood or adolescence, and males and females are equally affected. Sadly, patients rarely reach the age of 30. Biochemically, this disorder is characterized by a significant reduction in lysosomal acid lipase activity.   Thelansis’s “Cholesteryl Ester Storage Disease (CESD) Market Outlook, Epidemiology, Competitive Landscape, and Market Forec...