Thelansis

  The sickle cell trait represents a hereditary hematological anomaly characterized by a single abnormal allele of the hemoglobin beta gene. This contrasts with sickle cell disease, where both alleles are abnormal. Individuals with sickle cell trait typically exhibit no symptomatic manifestations related to sickling and thus generally experience an improved quality of life compared to sickle cell disease patients. Notably, individuals possessing the sickle cell trait do not demonstrate an elevated mortality risk relative to the general populace. This discourse delves into the assessment and treatment of sickle cell trait, emphasizing the collaborative efforts of the interdisciplinary team in enhancing the care provided to affected individuals. The genetic basis of the sickle cell trait is rooted in an atypical hemoglobin variant termed sickle hemoglobin (Hb S), resulting from a point mutation in the beta-globin chain. This genetic alteration entails a nucleotide substitution wher...