Thelansis

 Recessive dystrophic epidermolysis bullosa (RDEB) is a subgroup of hereditary blistering diseases known for their recurring injuries and healing processes, often leading to extensive scarring. These are part of a broader category of genetic skin disorders characterized by high susceptibility to blister formation and erosion triggered by minor injuries. There are more than 12 hereditary variations of epidermolysis bullosa (EB), grouped into four primary forms: dominant EB simplex, recessive junctional EB, dominant dystrophic EB, and recessive dystrophic EB. Dystrophic forms of EB entail repetitive skin injuries and subsequent healing, resulting in severe scarring. Notably, individuals with RDEB are prone to developing aggressive squamous cell carcinomas in regions with severe scarring, leading to significant health challenges and a shortened lifespan. The underlying mechanisms of Recessive dystrophic epidermolysis bullosa (RDEB) remain unclear, but researchers have explored two mai...

 Recessive dystrophic epidermolysis bullosa (RDEB) is a subgroup of hereditary blistering diseases characterized by repetitive wounding and healing with subsequent extensive scarring. It is a group of genetic skin disorders characterized by marked fragility and a tendency to form blisters and erosions in response to minor trauma. There are more than 12 hereditary types of EB, which are subclassified into four major forms: dominant EB simplex, recessive junctional EB, dominant dystrophic EB, and recessive dystrophic EB. Dystrophic forms of EB feature repetitive wounding and healing of the skin associated with severe scarring. A special feature of RDEB patients is a tendency to develop aggressive squamous cell carcinomas in areas of severe scarring. These cancers lead to high morbidity and mortality at a relatively early age. ·        The pathogenesis of Recessive dystrophic epidermolysis bullosa (RDEB) remains unclear; however, two hypotheses have bee...