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  Valneva SE, a specialty vaccine company, and LimmaTech Biologics AG, a clinical-stage biotech firm focused on preventing life-threatening diseases, have announced that the U.S. Food and Drug Administration (FDA) has granted Fast Track designation to Shigella4V (S4V). Shigella4V is the world’s most clinically advanced tetravalent bioconjugate shigellosis vaccine candidate, for which Valneva has obtained an exclusive worldwide license from LimmaTech. Publish Date: 16-10-2024   Source: Valneva SE Shigellosis is a bacterial infection caused by members of the genus Shigella, which belong to the tribe Escherichia in the family Enterobacteriaceae. The condition affects the digestive system and has two basic clinical presentations: watery diarrhoea associated with vomiting, mild to moderate dehydration, and dysentery characterized by a small volume of bloody mucoid stools and abdominal pain. The average duration of symptoms in untreated adults is seven days. Shigella species different

  Shigellosis is a bacterial infection caused by members of the genus Shigella, which belongs to the tribe Escherichia in the family Enterobacteriaceae. The condition affects the digestive system and has two basic clinical presentations: watery diarrhea associated with vomiting, mild to moderate dehydration, and dysentery characterized by a small volume of bloody mucoid stools and abdominal pain. The average duration of symptoms in untreated adults is seven days. Shigella species differentiated into four species: S dysenteriae (serogroup A, consisting of 12 serotypes); S flexneri (serogroup B, consisting of 6 serotypes); S. boydii (serogroup C, consisting of 18 serotypes); and S. sonnei (serogroup D, consisting of a single serotype). The hallmarks of shigellosis are the bacterial invasion of the colonic epithelium and inflammatory colitis, which results in the characteristic sign of bacillary dysentery: scanty, unformed stools tinged with blood and mucus. The diagnosis of shigellosis

 Shigellosis is a bacterial infection caused by members of the genus Shigella, which belong to the tribe Escherichia in the family Enterobacteriaceae. The infection affects the digestive system and has two basic clinical presentations: watery diarrhea associated with vomiting, mild to moderate dehydration, and dysentery characterized by a small volume of bloody mucoid stools and abdominal pain. In untreated adults, the average duration of symptoms is seven days, and the organism is cultivated from stools for 30 days or longer. Shigella species are classified into four species: S dysenteriae, S. boydii, S flexneri and S sonnei. The hallmarks of shigellosis are the bacterial invasion of the colonic epithelium and inflammatory colitis, resulting in the characteristic sign of bacillary dysentery: scanty, unformed stools tinged with blood and mucus. The diagnosis of shigellosis is usually confirmed by the cultivation of the etiologic agent from stools and slide agglutination using commercia