Thelansis

 Pseudoxanthoma elasticum (PXE) arises from mutations in the ABCC6 gene and is a hereditary metabolic disorder. It is characterized by the gradual calcification and breakage of elastic fibers in the skin, retina, and arterial walls. Typically, this condition manifests during adolescence or young adulthood, but it can emerge at any stage of life. The initial clinical indication is nearly always the appearance of small yellow papules on the back of the neck, sides of the neck, and in areas where the skin flexes. In some individuals, PXE may be confined to a single organ (skin, eyes, or blood vessels); in others, it can affect two or all three of these organs. Although cardiac issues like angina pectoris and myocardial infarction are relatively uncommon, they require thorough examination when present. Most PXE cases stem from two pathogenic variations in the ABCC6 gene, located at 16p13.11. In rare instances, patients displaying clinical features resembling PXE may possess pathogenic ...

  Pseudoxanthoma elasticum (PXE) is an inherited metabolic disorder due to  ABCC6  gene mutations. It is characterized by progressive calcification and fragmentation of elastic fibers in the skin, retina, and arterial wall. Despite calcium accumulation in the arteries of PXE patients, functional consequences remain unknown. According to the literature review conducted by Thelansis, the prevalence of PXE, estimated to be 1 in 50,000, would imply that there are ~8,000–10,000 PXE patients in the United States. With the same global prevalence, there could be as many as 160,000 to 200,000 patients affected with PXE worldwide. Thelansis’s “Pseudoxanthoma Elasticum (PXE) Market Outlook, Epidemiology, Competitive Landscape , and Market Forecast Report – 2021 To 2032" covers disease overview, epidemiology, drug utilization, prescription share analysis, competitive landscape, clinical practice, regulatory landscape, patient share, market uptake, market for...

  Pseudoxanthoma elasticum (PXE) is an inherited metabolic disorder due to ABCC6 gene mutations. It is characterized by progressive calcification and fragmentation of elastic fibers in the skin, retina, and arterial wall. Despite calcium accumulation in the arteries of PXE patients, functional consequences remain unknown.   Epidemiology- According to the literature review conducted by Thelansis, the prevalence of PXE estimated to be 1 in 50,000 would imply that there are ~8,000–10,000 PXE patients in the United States. With the same global prevalence, there could be as many as 160,000 to 200,000 patients affected with PXE worldwide.   The competitive landscape of Pseudoxanthoma elasticum (PXE) includes country-specific approved as well as pipeline therapies. Any asset/product-specific designation or review and Accelerated Approval are being tracked and supplemented with analyst commentary. KOLs insights of Pseudoxanthoma elasticum (PXE) across 8 MM market fro...