Thelansis

  Junctional epidermolysis bullosa (JEB) is characterized by skin and mucous membrane fragility, resulting in blistering with minimal or no trauma. The blistering can be severe, and granulation tissue may develop around the oral and nasal cavities, fingers and toes, and internally around the upper airway. In contrast to many other conditions, blisters in JEB typically heal without significant scarring. JEB is broadly classified into two categories: generalized severe and generalized intermediate. In JEB, generalized severe blisters are present at birth or appear in the neonatal period, often accompanied by congenital malformations of the urinary tract and bladder. JEB generalized intermediate may present with milder blistering localized to specific areas, such as hands, feet, knees, and elbows, with or without renal or ureteral involvement. Some individuals may not experience blistering after the newborn period. Common features shared with other forms of Epidermolysis bullosa (EB) in