Thelansis

  Leukocyte adhesion deficiency type I (LAD-I), a subtype of LAD defined in the terminology, is characterized by recurring bacterial infections that pose a life-threatening risk. Typically, the initial symptoms manifest during infancy or early childhood. Affected individuals frequently experience recurrent and life-threatening bacterial infections affecting the skin, mouth, and respiratory system. Delayed separation of the umbilical cord is a common occurrence. Skin infections may progress to the formation of extensive ulcers. In later stages of the condition, severe periodontitis often arises, leading to premature tooth loss. Notably, there is a lack of typical signs such as swelling, redness, heat, or pus in the infected areas. LAD-I arises due to mutations in the ITGB2 gene located at 21q22.3. This gene encodes for beta-2-integrin, known as CD18, which plays a vital role in facilitating the firm adhesion of leukocytes to the endothelium. The severity of the disease is closely ...

 Leukocyte adhesion deficiency type I (LAD-I), a subtype of LAD defined in the terminology, is characterized by recurring bacterial infections that pose a life-threatening risk. Typically, the initial symptoms manifest during infancy or early childhood. Affected individuals frequently experience recurrent and life-threatening bacterial infections affecting the skin, mouth, and respiratory system. Delayed separation of the umbilical cord is a common occurrence. Skin infections may progress to the formation of extensive ulcers. In later stages of the condition, severe periodontitis often arises, leading to premature tooth loss. Notably, there is a lack of typical signs such as swelling, redness, heat, or pus in the infected areas. LAD-I arises due to mutations in the ITGB2 gene located at 21q22.3. This gene encodes for beta-2-integrin, known as CD18, which plays a vital role in facilitating the firm adhesion of leukocytes to the endothelium. The severity of the disease is closely lin...