Thelansis

  Intermittent claudication (IC) is characterized by skeletal muscle pain in the lower extremities during exercise, resulting from insufficient oxygen delivery to meet metabolic demands. It is a prevalent manifestation of peripheral arterial disease (PAD), typically caused by atherosclerotic stenosis of arteries supplying the extremities. Pain is commonly felt in the thigh, hip, buttock, and calf muscles, induced by walking and alleviated with rest. The severity of pain often correlates with the degree of arterial stenosis. Reproducibility of muscle discomfort distinguishes intermittent claudication, with pain occurring during physical activity and subsiding after rest due to inadequate blood flow. It is frequently observed in patients with diabetes mellitus and individuals who smoke. Medical management offers effective treatment for most individuals with intermittent claudication. Therapies include cilostazol, blood pressure control, antiplatelet agents, statins, glycemic manage...