Thelansis

  Chronic rhinosinusitis without nasal polyposis (CRSsNP) manifests as the persistence of at least two out of four key symptoms over a period of 12 weeks or more: nasal obstruction, anterior or posterior nasal discharge, reduction or loss of smell, and facial pain/pressure/fullness. Additional symptoms may include rhinorrhea and facial discomfort. Conditions predisposing individuals to CRSsNP comprise acute rhinosinusitis, often triggered by viral respiratory infections, as well as allergic and non-allergic rhinitis, asthma, bronchitis, pneumonia, gastroesophageal reflux disease, adenotonsillitis, sleep apnea, and otitis media. Moreover, the likelihood of allergic conjunctivitis, atopic dermatitis, asthma, urinary tract infections, and skin/soft tissue infections increases with a diagnosis of CRSsNP. Traditionally, CRSsNP, typically associated with microbacterial colonization, has been presumed to arise from unresolved or insufficiently treated acute rhinosinusitis. However, this...