Thelansis

  Marie Unna hypotrichosis, an autosomal dominant disorder, exhibits sparse or absent hair at birth. This is followed by the emergence of coarse, wiry, twisted hair during childhood and eventually progresses to non-scarring hair loss at puberty. This final stage often follows a pattern similar to androgenetic alopecia. Affected individuals, regardless of gender, typically lack scalp hair, eyelashes, and eyebrows from birth. Their scalp hair transforms into a coarse and wiry texture in early childhood. The onset of scalp hair loss, resembling the pattern of androgenetic alopecia, begins around puberty and advances to near-complete baldness. The disorder results from mutations in U2HR, an inhibitory upstream open reading frame of the HR gene at 8p21.2. These mutations cause an overactivation of HR, leading to the condition. Globally, more than 30 affected families and sporadic cases, totaling around 20 U2HR mutations, have been identified. A Chinese family revealed a missense mutat...

  Marie Unna hypotrichosis, an autosomal dominant disorder, exhibits sparse or absent hair at birth. This is followed by the emergence of coarse, wiry, twisted hair during childhood and eventually progresses to non-scarring hair loss at puberty. This final stage often follows a pattern similar to androgenetic alopecia. Affected individuals, regardless of gender, typically lack scalp hair, eyelashes, and eyebrows from birth. Their scalp hair transforms into a coarse and wiry texture in early childhood. The onset of scalp hair loss, resembling the pattern of androgenetic alopecia, begins around puberty and advances to near-complete baldness. The disorder results from mutations in U2HR, an inhibitory upstream open reading frame of the HR gene at 8p21.2. These mutations cause an overactivation of HR, leading to the condition. Globally, more than 30 affected families and sporadic cases, totaling around 20 U2HR mutations, have been identified. A Chinese family revealed a missense mutatio...

Marie Unna hypotrichosis, an autosomal dominant disorder, exhibits sparse or absent hair at birth. This is followed by the emergence of coarse, wiry, twisted hair during childhood and eventually progresses to non-scarring hair loss at puberty. This final stage often follows a pattern similar to androgenetic alopecia. Affected individuals, regardless of gender, typically lack scalp hair, eyelashes, and eyebrows from birth. Their scalp hair transforms into a coarse and wiry texture in early childhood. The onset of scalp hair loss, resembling the pattern of androgenetic alopecia, begins around puberty and advances to near-complete baldness. The disorder results from mutations in U2HR, an inhibitory upstream open reading frame of the HR gene at 8p21.2. These mutations cause an overactivation of HR, leading to the condition. Globally, more than 30 affected families and sporadic cases, totaling around 20 U2HR mutations, have been identified. A Chinese family revealed a missense mutation in E...