Thelansis

 Leptomeningeal Metastases (LM) are defined as the spread of the disease to the meninges surrounding the brain and the spinal cord. They are a rare but frequently devastating complication of advanced cancer. When cancer cells are found in your leptomeninges or CSF, this is called leptomeningeal metastases (LM). LM stick onto nerves as they exit your brain and spinal cord, causing weakness and numbness. LM can also clog your leptomeninges and prevent CSF from being drained properly, causing CSF and pressure to build up inside your brain. LC is diagnosed in approximately 5% of patients with advanced cancer. However, it can be detected in up to 20% of cases in autopsy studies. LC is most frequently associated with breast cancer, lung cancer, melanoma, gastrointestinal cancer, and cancer of unknown primary. Also, it can be detected in primary brain tumors and hematologic malignancies. The prognosis of LC is poor, with median survival ranging from 4–6 weeks when untreated to 2–3 months ...