Thelansis

 Cisplatin-induced hearing loss (CIHL) can arise due to various predisposing factors such as pre-existing conditions like hypoalbuminemia, anemia, renal failure, and noise-induced hearing loss, or from certain risk factors like the administration of loop diuretics, aminoglycoside antibiotics, radiotherapy affecting the inner ear, extremes of age (very young or elderly), as well as the duration and dosage regimen of cisplatin infusion, alongside genetic predispositions. Research indicates that between 11% and 97% of patients treated with cisplatin experience hearing loss, with an average occurrence rate of 62%. Cisplatin-induced tinnitus is also not uncommon. Ototoxicity can manifest within hours to days following cisplatin administration. Cisplatin primarily damages outer hair cells, progressing from the third to the first row, and to some extent affects inner hair cells of the organ of Corti in the basal turn of the cochlea, followed by alterations in sensorial cells located in th...

 Cisplatin-induced hearing loss (CIHL) is favored either by pre-existing afflictions like hypoalbuminemia, anemia, renal failure, and noise-induced hearing loss or by risk factors like therapy with loop diuretics, aminoglycoside antibiotics, radiotherapy fields which includes the inner ear, extreme ages (very young or very old), duration and dose schedule of cisplatin infusion, and genetic factors. Between 11% and 97% of patients treated with cisplatin develop hearing loss, with an average incidence of 62%. Cisplatin-induced tinnitus is not an infrequent occurrence either. Ototoxicity may occur within hours to days after cisplatin administration. Cisplatin inflicts injuries mainly to outer hair cells, progressing from the third to the first row and to some extent to inner hair cells of the organ of Corti in the basal turn of the cochlea followed by alterations in sensorial cells situated in the apex. Cisplatin also targets supporting cells, marginal cells of the stria vascularis, a...