Thelansis

  Lewy body diseases (LBDs) encompass a range of clinical conditions, including Parkinson's disease (PD), Parkinson's disease dementia (PDD), and dementia with Lewy bodies (DLB), which collectively exhibit a spectrum of both motor and cognitive symptoms. PD and PDD initially manifest with motor dysfunctions like resting tremors, bradykinesia, and impaired gait, which may progress to cognitive deficits. Conversely, DLB predominantly showcases cognitive impairments, often evolving to encompass Parkinsonian features like those observed in PD. The distinctive pathological hallmark of LBD involves the presence of intraneuronal aggregations of α-synuclein protein, referred to as Lewy bodies. Alongside Lewy body presence, cases of LBD exhibit discernible nigral depigmentation and striatonigral dopaminergic denervation, factors thought to underlie the extrapyramidal manifestations characteristic of clinical parkinsonism. The precise mechanistic significance of Lewy bodies to the neur...