Thelansis

 PIK3CA-related overgrowth spectrum (PROS) is a group of rare disorders that cause an overgrowth of body parts due to mutations in the PIK3CA gene. PIK3CA-related overgrowth spectrum (PROS) encompasses a range of clinical findings in which the core features are the congenital or early-childhood onset of segmental/focal overgrowth with or without cellular dysplasia. Somatic mutations in the PIK3CA gene usually cause PROS. These changes are typically limited to specific cells or areas of the body and are not known to be inherited. PROS is occasionally caused by a de novo germline mutation present in all body cells. A PROS disorder can be confirmed through genetic testing of the PIK3CA gene. There is currently no cure for the PIK3CA-related overgrowth spectrum (PROS). However, treatment options are available to help manage the syndromes' symptoms. Overgrowth may be treated surgically to remove growths that impair movement. ·        PIK3CA-related overgr...

  PIK3CA-related overgrowth spectrum (PROS) is a group of rare disorders that cause an overgrowth of body parts due to mutations in the PIK3CA gene. PIK3CA-related overgrowth spectrum (PROS) encompasses a range of clinical findings in which the core features are the congenital or early-childhood onset of segmental/focal overgrowth with or without cellular dysplasia. Somatic mutations in the PIK3CA gene usually cause PROS. These changes are typically limited to specific cells or areas of the body and are not known to be inherited. PROS is occasionally caused by a de novo germline mutation present in all body cells. A PROS disorder can be confirmed through genetic testing of the PIK3CA gene. There is currently no cure for the PIK3CA-related overgrowth spectrum (PROS). However, treatment options are available to help manage the syndromes' symptoms. Overgrowth may be treated surgically to remove growths that impair movement.   PIK3CA-related overgrowth spectrum (PROS) prevalen...